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Bone Marrow Culture Studies in Refractory Cytopenia and ‘Smouldering Leukaemia’
Author(s) -
Milner Gillian R.,
Testa Nydia G.,
Geary C. G.,
Dexter T. M.,
Muldal S.,
Maciver J. E.,
Lajtha L. G.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb00582.x
Subject(s) - cytopenia , bone marrow , refractory (planetary science) , platelet , pathology , myelodysplastic syndromes , biology , immunology , medicine , astrobiology
As an adjunct to conventional haematological and cytogenetic data, 22 cases of refractory cytopenia, and five with chronic myelomonocytic leukaemia, (CMML) were studied by bone marrow culture. Cultures from 11 such patients without an excess of marrow myeloblasts usually showed low, or undetectable, numbers of cells capable of giving rise to colonies of granulocytes and/or macrophages (CFU C ) but near‐normal numbers of cluster‐forming cells and cells capable of forming erythroid colonies (CFU E ). Those with similar blood pictures, but in whom the marrow contained a slight excess of myeloblasts (11 cases), showed a more profound defect in growth patterns: low or undetectable numbers of CFU C , clusters and CFU E , results similar to those found in acute myeloblastic leukaemia, into which three of this group evolved. The patients with CMML gave comparatively normal CFU C , cluster and CFU E growth patterns.