Premium
Neutrophil Function in Bone Marrow Transplant Recipients
Author(s) -
Territo Mary C.,
Gale Robert P.,
Cline Martin J.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb00581.x
Subject(s) - phagocytosis , candida albicans , immunology , staphylococcus aureus , medicine , bone marrow , chemotaxis , pneumonia , bone marrow transplantation , pneumocystis carinii , transplantation , biology , microbiology and biotechnology , bacteria , human immunodeficiency virus (hiv) , receptor , genetics , pneumocystis jirovecii
The neutrophil function of seven patients receiving allogeneic bone marrow transplantation was studied. Five of the patients had been transplanted for aplastic anaemia and two for acute leukaemia. Determinations were made of neutrophil phagocytosis, chemotaxis, random migration, and microbicidal activity for Candida albicans and Staphylococcus aureus . One patient showed a decreased ability to kill C. albicans at a time when she had active pneumonia due to Pneumocystis carinii . The remainder of the studies showed normal neutrophil functions. No differences were observed in the patients who had graft versus host disease (GvH) from those without GvH. These studies suggest that defects in phagocytic neutrophil function do not contribute significantly to the impaired host defenses in recipients of bone marrow transplantation.