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Reversal of Ineffective Erythropoiesis in Pernicious Anaemia following Vitamin B 12 Therapy
Author(s) -
Samson Diana,
Halliday D.,
Chanarin I.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb00578.x
Subject(s) - erythropoiesis , ineffective erythropoiesis , pernicious anaemia , vitamin b12 , pernicious anemia , medicine , vitamin b , endocrinology , anemia , chemistry , vitamin
Ineffective erythropoiesis was quantitated in a series of patients with pernicious anaemia at different times in relation to vitamin B 12 therapy by measuring the incorporation of [ 15 N]δ aminolaevulinic acid and [ 15 N]glycine into early labelled bilirubin. Prior to therapy ineffective erythropoiesis was grossly increased but this was reversed within 24 h of giving vitamin B 12 , suggesting that most of the existing megaloblasts are enabled to mature into circulating red cells.