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Ferrokinetics and Erythropoiesis in Man: Red‐Cell Production and Destruction in Normal and Anaemic Subjects
Author(s) -
Cavill I.,
Ricketts C.,
Napier J. A. F.,
Jacobs A.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb00560.x
Subject(s) - erythropoiesis , red cell , ineffective erythropoiesis , medullary cavity , iron deficiency , medicine , bone marrow , bone marrow diseases , anemia , endocrinology , immunology
Recent advances in the analysis of plasma 59 Fe clearance have produced a unified method for measuring effective and ineffective erythropoiesis (Ricketts et al , 1975). We have used this method to investigate the balance between red‐cell production and destruction in normal subjects and in patients with megaloblastic anaemia, iron deficiency anaemia and refractory hypoplastic anaemia. The results show that the normal marrow can maintain an appropriate red‐cell mass by altering red‐cell production to match destruction. In the anaemias we have studied there is an increased rate of either intra‐ or extra‐medullary red‐cell destruction. The response of the marrow may be limited by iron supply, by defective nuclear maturation or by some intrinsic marrow defect.