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Neutrophil Accumulation in Vivo following the Administration of Chemotactic Factors
Author(s) -
Jones D. G.,
Richardson D. L.,
Kay A. B.
Publication year - 1977
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1977.tb00558.x
Subject(s) - in vivo , chemotaxis , in vitro , potency , guinea pig , complement component 5 , chemistry , sephadex , pharmacology , immunology , homologous chromosome , complement system , granulocyte , biology , biochemistry , endocrinology , receptor , antibody , enzyme , microbiology and biotechnology , gene
Intravenously administered 51 Cr‐labelled homologous neutrophils accumulated at guinea‐pig skin sites prepared by intradermal injection of factors derived from complement‐activated serum, possessing in vitro chemotactic activity. There was a strong correlation between the in vitro potency of Sephadex G‐100 fractions of the activated serum and their ability to evoke neutrophil accumulation in vivo. These experiments suggest that agents which are chemotactic for neutrophils in vitro also induce the localization of this cell in vivo.