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Studies on Calcium Transport and Calcium‐dependent Adenosine Triphosphatase Activity of Erythrocyte Membranes in Hereditary Spherocytosis
Author(s) -
ZAIL S. S.,
HOEK ANNE K. VAN DEN
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03607.x
Subject(s) - hereditary spherocytosis , adenosine triphosphatase , calcium , spherocytosis , chemistry , membrane , erythrocyte membrane , triphosphatase , biochemistry , spleen , medicine , atpase , enzyme , splenectomy , organic chemistry
S ummary . Evidence has been recently presented of a relative deficiency of Ca 2+ ‐dependent adenosine triphosphatase activity of erythrocyte membranes obtained from patients with hereditary spherocytosis. We have sought to confirm these findings by measuring calcium efflux from intact erythrocytes of patients with hereditary spherocytosis, as well as erythrocyte calcium concentrations, but find both these parameters to be normal. Ca 2+ ‐dependent adenosine triphosphatase activity, as well as Ca 2+ ‐dependent membrane phosphorylation was also not found to be deficient in erythrocyte membranes from subjects with hereditary spherocytosis. These studies do not support the postulate that an accumulation of calcium affects the deformability of erythrocytes and their subsequent destruction in the spleen.