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An Inhibitor of Stem Cell Proliferation in Normal Bone Marrow
Author(s) -
LORD B. I.,
MORI K. J.,
WRIGHT E. G.,
LAJTHA L. G.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03590.x
Subject(s) - bone marrow , spleen , population , stem cell , biology , thymidine , cell , cell growth , precursor cell , cell division , trypsin , microbiology and biotechnology , immunology , chemistry , biochemistry , in vitro , medicine , enzyme , environmental health
S ummary . A saline extract from normal bone marrow cells having a molecular weight in the range 50 000–100 000 daltons has been found to protect rapidly proliferating haemopoietic spleen colony forming cells (CFU s ) from the lethal effects of large doses of tritiated thymidine. This extract is non‐toxic to the cells. It is not found in regenerating marrow where the CFU s population is rapidly proliferating. Its effect appears to be specific for the CFU s since it has no effect on the proliferation of its close descendant, the granulocytic precursor cell (CFU c ), and no effect on the average cytoplasmic structuredness of the whole bone marrow cell population. The active material is probably protein since it is degraded by trypsin.