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Bleeding from Self‐administration of Phenindione: a Detailed Case‐study
Author(s) -
Gover P. A.,
Ingram G. I. C.,
Cork M. S.,
Holland L.,
Hopkins R. P.,
Callaghan P.,
Barkhan P.,
Shearer M. J.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03574.x
Subject(s) - medicine
S ummary . A young woman presented with a 2 year history of a severe bleeding disorder and marked deficiencies in all four vitamin‐K‐dependent factors. Metabolic studies with tracer doses of tritium‐labelled vitamin K 1 suggested that the patient might be taking an oral anticoagulant; and subsequently her plasma was found to contain a substance identical to phenindione in its spectrophotometric and chromatographic properties. The half‐disappearance times of factors II, IX, X were measured after the administration of a concentrate of these factors and were found to conform with published figures. The concentrate controlled the patient's excessive bruising and prolonged skin and gingival bleeding. It would therefore seem that factor VII may not be essential in reversal of the bleeding disorder induced by anticoagulant overdose.