Premium
Chelation Studies with 2,3‐Dihydroxybenzoic Acid in Patients with β‐Thalassaemia Major
Author(s) -
Peterson C. M.,
Graziano J. H.,
Grady R. W.,
Jones R. L.,
Vlassara H. V.,
Canale V. C.,
Miller D. R.,
Cerami A.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03566.x
Subject(s) - excretion , chelation , drug , chelation therapy , calcium , medicine , pharmacology , magnesium , thalassemia , chemistry , inorganic chemistry , organic chemistry
S ummary . 2,3‐Dihydroxybenzoic acid was evaluated as a potentially useful, orally effective iron‐chelating drug by performing iron balance studies in patients with β‐thalassaemia major. The administration of this substance at 25 mg/kg/d to five patients for 8 d caused an average increase in iron excretion of 4.5 mg/d. When the drug was administered at 25 mg/kg q.i.d. to eight patients for 21 d, iron excretion increased to 6.5 mg/d. Chelation was highly specific for iron with changes in magnesium and calcium excretion being insignificant. The drug was well tolerated with side effects limited to gastrointestinal complaints which ameliorated when the drug was taken with food. These studies provide a rationale for further evaluation of 2,3‐dihydroxybenzoic acid in patients with iron overload.