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Intercellular Contacts between Erythroid Precursors in the Bone Marrow in Dyserythropoiesis
Author(s) -
Frisch B.,
Lewis S. M.,
Swan M.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03565.x
Subject(s) - erythropoiesis , microbiology and biotechnology , intracellular , ineffective erythropoiesis , ultrastructure , bone marrow , biology , cell junction , cell , chemistry , immunology , anatomy , biochemistry , anemia , medicine
S ummary . The ultrastructure of the cellular interfaces between erythroid precursors has been studied in both congenital and acquired dyserythropoiesis. The types of cell‐to‐cell contacts found included highly convoluted interdigitating septate‐like junctions as well as apparent confluence of the cellular membranes of adjacent erythroid cells. Such findings are not characteristic of the intercellular relationships found in the normal erythroblastic islands. The erythroid plasma membrane modifications are possibly related to the changes in the plasma membranes of erythroid cells known to occur in dyserythropoiesis and their presence may well contribute to the ineffective erythropoiesis with intramedullary cell destruction which characterizes many dyserythropoietic states.