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Control of Haemopoietic Stem Cell Proliferation by Cells in DNA Synthesis
Author(s) -
Nečas E.,
Neuwirt J.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03556.x
Subject(s) - mitosis , dna synthesis , microbiology and biotechnology , stem cell , biology , colchicine , cell cycle , cell growth , population , cell division , induced pluripotent stem cell , dna damage , cell , dna , genetics , embryonic stem cell , medicine , gene , environmental health
S ummary . It has been demonstrated that for the slowly proliferating population of the haemopoietic pluripotent stem cells (CFU s ) the response after damage by hydroxyurea to cells synthesizing DNA differs from that after damage by colchicine to cells entering mitosis. The killing of DNA synthesizing cells elicits increased proliferation in the CFU s population. From this it has been inferred that cells in the S phase may inhibit the entry of nonproliferating G 0 cells into the cell cycle and in this way control cellular proliferation.