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The Efffects of Acute Bleeding on Acid–Base Balance, Erythropoietin (Ep) Production and in Vivo P 50 in the Rat
Author(s) -
Miller Marilyn E.,
Rörth M.,
Stohlman F.,
Valeri C. R.,
Lowrie G.,
Howard D.,
McGilvray Norah
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03554.x
Subject(s) - in vivo , erythropoietin , red cell , chemistry , red blood cell , respiratory alkalosis , perfusion , alkalosis , oxygen , hypoxia (environmental) , biochemistry , endocrinology , medicine , biology , acidosis , metabolic acidosis , microbiology and biotechnology , organic chemistry
S ummary . The mechanism of erythropoietin (Ep) production after acute haemorrhage has been thought to be due to a reduction in blood volume and tissue perfusion leading to tissue hypoxia. In the present study we have evaluated the effect of acute haemorrhage in the rat on the acid‐base status, the red cell affinity for oxygen in vivo , and Ep production. Within a few hours after acute blood loss there was a respiratory alkalosis with an increase in blood pH, a decrease in pCO 2 and an increase in the red cell affinity of Hb for oxygen in vivo that was temporally related to an increase in Ep production. Within 24 h after the acute haemorrhage, the blood pH and pCO 2 , red cell affinity for oxygen in vivo , and Ep level returned towards normal. The decrease in in vivo red cell affinity for oxygen was associated with an increase in red cell 2,3‐DPG levels and a decrease in Ep production.