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Severe Hereditary Haemolytic Anaemia in Dogs Treated by Marrow Transplantation
Author(s) -
Weiden Paul L.,
Storb Rainer,
Graham Theodore C.,
Schroeder MariaLouise
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03551.x
Subject(s) - medicine , bone marrow transplantation , transplantation , immunology
S ummary . Severe hereditary haemolytic anaemia related to pyruvate kinase deficiency occurs in Basenji dogs homozygous for this autosomal recessive defect. In the current study, three anaemic dogs were treated by total body irradiation and marrow transplantation from non‐anaemic histocompatible littermates with resultant complete correction of their haemolytic anaemia. The possible use of marrow transplantation for life‐threatening haemolytic anaemias in man is discussed.