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The Relationship between Total Red Cell Volume, Plasma Volume and Venous Haematocrit
Author(s) -
Bentley S. A.,
Lewis S. M.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03542.x
Subject(s) - plasma volume , hematocrit , volume (thermodynamics) , blood volume , red cell , medicine , cardiology , intensive care medicine , physics , quantum mechanics
S ummary . Total red cell volume (TRCV) and plasma volume (PV) have been measured in 130 cases including 65 polycythaemic patients and 65 patients with a wide variety of disorders. Patients with gross splenomegaly were excluded from the study. The regression of TRCV on venous haematocrit (VHct) was found to be curvilinear, a single exponential function providing a good approximation ( r = 0.92, P < 0.001). No significant difference was found between the mean PVs of the polycythaemic and control groups (40.97 and 42.94 ml/kg respectively) although a slight but highly significant negative correlation was observed between PV and VHct ( r = 0.47, P < 0.001). This was most marked for patients with VHcts below 0.30, for whom a separate plot yielded a correlation coefficient of 0.75. Total blood volume (TBV) and VHct were found to be positively correlated ( r = 0.57, P < 0.001) as would be expected from the TRCV and PV data. The significance of these findings is discussed.