Premium
The Effect of Some Anticonvulsant Drugs on Depletion of Folate in Rats on a Vitamin B 12 ‐Deficient Diet
Author(s) -
Williams D. L.,
Spray G. H.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb03538.x
Subject(s) - anticonvulsant , anticonvulsant drugs , pharmacology , vitamin , chemistry , vitamin b , b vitamins , folic acid , medicine , epilepsy , endocrinology , biochemistry , psychiatry
S ummary . Rats fed on vitamin B 12 ‐deficient or vitamin B 12 ‐supplemented diets and treated with phenobarbitone by intraperitoneal injection for 5 d showed significant increases in the activity of glutamate formiminotransferase in liver. The only significant depletion in liver folate activity was in vitamin B 12 ‐supplemented rats that were starved for 48 h. When rats were given the same diets, with phenobarbitone and diphenylhydantoin added, for 12 weeks or more in two separate experiments, significant increases in transferase activity were found only in the livers of animals fed on the deficient diet. However, there was significant depletion of liver folate in animals taking the supplemented diet.