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Lack of Prognostic Value of Lymphoblast Size in Acute Lymphoblastic Leukaemia
Author(s) -
Oster Martin W.,
Margileth David A.,
Simon Richard,
Leventhal Brigid G.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00979.x
Subject(s) - lymphoblast , medicine , gastroenterology , overall survival , immunology , pediatrics , biology , genetics , cell culture
S ummary . There are conflicting reports about the relationship of cell size and type to prognosis in acute lymphoblastic leukaemia (ALL). For this reason, bone marrows at diagnosis and first relapse were studied in 56 children with ALL treated on the same protocol. Lymphoblasts greater than 12 mμ in diameter were called macrolym‐phoblasts (MLB). Forty‐one of 56 initial bone marrows had less than 20% MLB (group A), and 15 had greater than 20% MLB (group B). Median survival, complete remission rate, first remission duration, and the distribution of CNS leukaemia were similar in both groups. First relapse marrows were examined from 50 patients and a significant increase in MLB compared to initial pre‐treatment bone marrows (18% vs 8%) was found.