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Lymphocyte Response to Blood Transfusion in Man: a Comparison of Different Preparations of Blood
Author(s) -
Hutchinson R. M.,
Sejeny S. A.,
Fraser I. D.,
Tovey G. H.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00976.x
Subject(s) - antibody , blood transfusion , immunology , whole blood , medicine , transfusion reaction , lymphocyte , thymidine , cytotoxic t cell , dextran , chemistry , biochemistry , dna , in vitro
S ummary . The appearance of atypical lymphocytes in post‐transfusion blood, their incorporation of tritiated thymidine in tissue culture and the elimination of cytotoxic antibody production, have been used as markers to show that frozen red cells are the least immunogenic when compared with dextran sedimented blood and whole blood donations. The absence of atypical lymphocytes and failure to produce lympho‐cytotoxic antibodies after transfusion of frozen cells is highly significant ( P <0.001) when compared with whole blood donations.