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Prophylaxis in Haemophilia: A Double‐blind Controlled Trial
Author(s) -
Aronstam A.,
Arblaster P. G.,
Rainsford S. G.,
Turk P.,
Slattery M.,
Alderson M. R.,
Hall D. E.,
Kirk P. J.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00973.x
Subject(s) - haemophilia , medicine , double blind , haemophilia a , intensive care medicine , pediatrics , alternative medicine , placebo , pathology
S ummary . A double‐blind controlled trial of prophylactic factor VIII therapy has been carried out on nine severe haemophiliacs at the Lord Mayor Treloar College. Infusions were given once weekly and calculated to give a post‐infusion plasma concentration of at least 0.25 I.U./ml of factor VIII. This regime reduced the overall bleeding frequency by 15%. The bleeding frequency in the first 3 days post‐infusion was reduced by 66%. A moderate overall reduction in morbidity was also achieved. It is calculated that to reduce the incidence of bleeding in severe haemophiliacs by 15% would require a 73% increased usage of therapeutic materials. More than twice this amount of material is likely to be needed to reduce the bleeding frequency of the same group by 66%.