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Residual Marrow Damage: Possible Explanation for Idiosyncrasy to Chloramphenicol
Author(s) -
Morley Alec,
Trainor Kevin,
Remes Judith
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00955.x
Subject(s) - idiosyncrasy , chloramphenicol , bone marrow , progenitor cell , residual , biology , medicine , stem cell , immunology , microbiology and biotechnology , antibiotics , biochemistry , finance , algorithm , computer science , economics
The effect of oral administration of chloramphenicol was studied in normal mice and mice having residual marrow damage. In the concentration used the drug had no detectable effect on the marrow of normal mice but caused a progressive fall in the numbers of pluripotential stem cells and granulocytic progenitor cells in mice bearing residual marrow damage. However, cells taken from such mice were no more sensitive than normal cells to the in vitro action of chloramphenicol. The results suggest that unrecognized residual marrow damage can be an aetiological factor in marrow failure due to drug idiosyncrasy.