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The Primary Rh 0 (D) Immune Response in Male Volunteers
Author(s) -
Gunson H. H.,
Stratton F.,
Phillips P. K.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00935.x
Subject(s) - immunogenicity , immune system , antigen , stimulus (psychology) , immunology , medicine , psychology , psychotherapist
After a single antigenic stimulus, not greater than 5.0 ml R 2 R 2 red cells, anti‐D was detected in 79% of D‐negative volunteers increasing to 88% after subsequent spaced stimuli. The use of repeated antigenic stimuli at 2‐ or 4‐weekly intervals to induce the immune response did not appear to increase the frequency of responders. The results obtained are compared with those of other workers and evidence is presented to suggest that the immunogenicity of red cells from different donors may have a role in determining the frequency of responders with detectable anti‐D and is possibly associated with the R 2 antigenic complex.