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The Significance of Plasma Lipoproteins on Erythrocyte Aggregation and Sedimentation
Author(s) -
Scherer R.,
Morarescu A.,
RuhenstrothBauer G.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00926.x
Subject(s) - sedimentation , plasma lipoprotein , erythrocyte aggregation , erythrocyte sedimentation rate , chemistry , medicine , biochemistry , biology , lipoprotein , cholesterol , fibrinogen , paleontology , sediment
Increased erythrocyte aggregation can be induced by high concentrations of human lipoproteins. The dependence of aggregate formation on lipoprotein concentration was recorded by determination of erythrocyte sedimentation rate (ESR), by electrical measurement of the erythrocyte aggregation index (EAI) and by scanning electron microscopy. The lipoprotein concentrations necessary to induce a significantly increased ESR in an otherwise normal human plasma are much too high to be encountered in physiologic or even severe pathologic states. Therefore hyperlipoproteinaemia by itself cannot explain a raised ESR. In cases where the ESR is raised due to the presence of increased amounts of other erythrocyte aggregating plasma proteins (agglomerins), hyperlipoproteinaemia can contribute to a limited extent to the increase in ESR. The possible pathophysiological significance of the demonstrated erythrocyte aggregating capacity of human liproteins in a microvascular environment is noted.