Premium
Carbon Monoxide Production in Patients with Breast Carcinoma
Author(s) -
CavallinStarhl Eva,
Mercke C.,
Lundh B.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00920.x
Subject(s) - carbon monoxide , breast carcinoma , carcinoma , medicine , production (economics) , oncology , breast cancer , chemistry , cancer , biochemistry , economics , macroeconomics , catalysis
Total haem catabolism has been studied through measurement of endogenous production of carbon monoxide ( V co) in 19 patients treated for breast carcinoma. The subjects were divided into three groups. Group A included six patients with haemoglobin (Hb) concentration greater than 11.5 g/dl and considered free from disease. Group B consisted of seven patients with distant metastases and Hb concentration greater than 11.5 g/dl and group C of six patients with distant metastases and anaemia (Hb concentration less than 11.5 g/dl). V co in group A was 10.3 ± 3.7 (mean±1 SD) and in group B 9.0±2.5 μmol/mmol total body haem (TBH)/d. These values are not different from our normal values of 10.8 ± 2.8 μmol/mmol TBH/d. In group C V co was 21.1 ± 3.1 (an increase of 100%). V co was compared to daily catabolism of circulating red cell haemoglobin haem ( V haem‐c) in the V co/ V haem‐c quotient. V haem‐c was calculated from total circulating red cell haemoglobin haem (TBHb‐c) and red cell survival. In group A and group B this quotient was 1.3 ± 0.6 and 1.1 ± 0.2, respectively, and in group C was 2.5 ± 0.9. The difference between group A and B on one side and group C on the other side was significant ( P <0.001). The ‘extra’ CO produced in patients with anaemia and disseminated disease (group C) was thought to originate from increased turnover of bone marrow haem, reflecting considerable ineffective erythropoiesis with destruction of haemoglobinized immature red cells. The results confirm earlier findings of a high V co/ V haem‐c quotients in patients with anaemia secondary to Hodgkin's disease.