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Different Antiplatelet Antibody Specificities in Immune Thrombocytopenic Purpura
Author(s) -
DONNELL R. L.,
Mcmillan R.,
Yelenosky R. J.,
Longmire R. L.,
Lightsey A. L.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00183.x
Subject(s) - platelet , antibody , thrombocytopenic purpura , antigen , immunology , incubation , incubation period , immune system , medicine , chemistry , biochemistry
SUMMARY It is generally accepted that patients with immune thrombocytopenic purpura (ITP) produce antibody against platelet‐associated antigens; however, it is not known if these antiplatelet antibodies are directed towards the same or different antigenic sites. In the present studies, quantities of antiplatelet antibody from different ITP patients, sufficient to saturate platelet antigenic sites, were simultaneously incubated with normal platelets and the quantity of platelet‐binding IgG (PBIgG) was determined. In each of the five comparisons made, the amount of PBIgG bound after incubation of normal platelets with saturating quantities of two ITP antibodies approximated to the sum of the PBIgG bound after incubation with the antibodies separately. These data suggest that the antiplatelet antibody from these ITP patients differed in antigenic specificity.