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Unbalanced Globin Chain Synthesis in Erythroid Precursor Cells of Heterozygous αThalassaemia
Author(s) -
Steinberg Martin H.,
Coleman Mary,
Dreiling Bernard
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00173.x
Subject(s) - heterozygote advantage , globin , beta (programming language) , alpha (finance) , reticulocyte , hemoglobinopathy , biology , microbiology and biotechnology , beta thalassaemia , chemistry , immunology , genetics , hemoglobin , thalassemia , hemolytic anemia , biochemistry , gene , medicine , genotype , rna , construct validity , nursing , computer science , patient satisfaction , programming language
SUMMARY Globin biosynthesis was studied in both erythroid precursors and reticulocytes of three individuals with heterozygous αthalassaemia. In contrast to the finding of equal or nearly equal α and β chain synthesis in the marrow of patients with heterozygous β‐thalassaemia previously examined, our studies showed equal degrees of unbalanced globin synthesis in both reticulocytes and nucleated erythroid cells of αthalassaemia heterozygotes. Greater stability and less susceptibility to proteolysis of the excess β‐chain formed in αthalassaemia may explain our findings.