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Quantitation of Ineffective Erythropoiesis from the Incorporation of [ 15 N]Delta‐aminolaevulinic Acid and [ 15 N]Glycine into Early Labelled Bilirubin: I. NORMAL SUBJECTS
Author(s) -
SAMSON Diana,
HALLIDAY D.,
Nicholson D. C.,
Chanarin I.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00171.x
Subject(s) - glycine , erythropoiesis , bilirubin , ineffective erythropoiesis , chemistry , medicine , biochemistry , amino acid , anemia
SUMMARY The incorporation of [ 15 N]glycine into early labelled bilirubin and haemoglobin haem was measured in four haematologically normal subjects, using the clearance of [ 14 C] bilirubin to measure total bilirubin production rate. Hepatic haem turnover was calculated from the incorporation of [ 15 N]δ‐aminolaevulinic acid into early labelled bilirubin. From the experimental data and previously published data in normal subjects a method is derived for the quantitation of ineffective erythropoiesis which can be applied to similar studies in patients with haemato‐logical disorders.