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Another Example of an Antibody Reacting Optimally with p Red Cells
Author(s) -
Issitt C. H.,
Duckett J. B.,
Osborne B. M.,
Gut J. B.,
Beasley J.
Publication year - 1976
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1976.tb00169.x
Subject(s) - phenotype , antibody , gene , antigen , red cell , microbiology and biotechnology , biology , chemistry , immunology , genetics , medicine
SUMMARY An antibody is described that reacted strongly with red cells of the p(Tj(a —)) phenotype and moderately to strongly with cord red cells of the P 2 phenotype. The antibody failed to react, or reacted very weakly, with red cells of the P 1 k and P 1 phenotypes and with the red cells of five children of a p individual, and reacted weakly with occasional red cell samples from adults of the P 2 phenotype. These results suggest that the antibody does not detect a product of the p , gene but instead detects a P system precursor substance. In p individuals this P system precursor substance is not altered by the p , genes. In individuals of the P 1 or P 2 phenotype this precursor substance is apparently converted to P 1 and/or P antigens by the P 1 or P 2 genes,