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The Ultrastructure of Dyserythropoiesis in Aplastic Anaemia
Author(s) -
Frisch B.,
Lewis S. M.,
Sherman D.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb02741.x
Subject(s) - erythropoiesis , ultrastructure , endoplasmic reticulum , nuclear membrane , multinucleate , biology , pathology , heterochromatin , microbiology and biotechnology , microtubule , cell nucleus , ineffective erythropoiesis , intracellular , lamin , chromatin , anatomy , nucleus , medicine , genetics , anemia , dna
S ummary Electron microscopy of erythropoiesis in aplastic anaemia has demonstrated some unique features of dyserythropoiesis at the ultrastructural level, which contribute to understanding the morphological features which are seen in the light microscope. The findings provide further evidence for the presence of qualitative defects in erythropoiesis in aplastic conditions. The alterations seen included bi‐and multinucleated cells, intercellular bridges containing microtubules, inter‐nuclear chromatin bridges, irregular nuclear shapes, juxta‐nuclear and peripheral cisternal structures, ringed sideroblasts, a diversity of intranuclear inclusions, nuclear clefts in both eu‐ and heterochromatin, and a variety of anomalies of the nuclear membrane. The significance of the occurrence of these anomalies in aplastic anaemia is considered and the role of the nuclear membrane and of endoplasmic reticulum in the pathogenesis of aplastic anaemia is discussed.