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Pure Red Cell Aplasia: Studies on an IgG Serum Inhibitor Neutralizing Erythropoietin
Author(s) -
Peschle Cesare,
Marmont Alberto M.,
Marone Gianni,
Genovese Arturo,
Sasso Guido F.,
Condorelli Mario
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb01855.x
Subject(s) - pure red cell aplasia , erythropoietin , medicine , aplasia , antibody , immunology , gamma globulin , anemia , chemistry , endocrinology
S ummary . A new type of IgG serum inhibitor in adult pure red cell aplasia (PRCA) has been investigated. This inhibitor is directed against circulating erythropoietin (Ep) (PRCA type B), rather than the erythroid marrow (PRCA type A). Thus, the IgG inhibitor, after interaction with Ep in solution, is precipitated together with Ep by addition of goat anti‐human gamma‐globulins. Pre‐therapy PRCA serum, although apparently devoid of Ep, shows considerable Ep activity following acidification and boiling. The inhibitor is absent from post‐therapy serum, while Ep levels are elevated. An experimental model for PRCA type B has been established in normal mice after prolonged administration of pre‐remission serum IgG.