Premium
Thymoma Associated with Pure Red Cell Aplasia, Immunoglobulin Deficiency and an Inhibitor of Antigen‐induced Lymphocyte Transformation
Author(s) -
Geary C. G.,
Byron P. R.,
Taylor G.,
Maciver J. E.,
Zervas J.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb01845.x
Subject(s) - pure red cell aplasia , thymoma , immunology , antibody , antigen , lymphocyte , medicine , bone marrow
S ummary . A case of thymoma associated with pure red cell aplasia and hypogammaglobulinemia is described in which the anaemia was of abrupt onset, following removal of the tumour. Tests of immunological function showed abnormalities of both humoral and cellular immunity. The patient was found to have a serum inhibitor of antigen‐induced lymphocyte transformation which disappeared after immunosuppressive therapy at the same time that erythroblasts reappeared in the marrow. It is suggested that the triad of thymoma, pure red cell aplasia and immunoglobulin deficiency are manifestations of ‘pluripotent’ stem cell failure; in this case the inhibitor of lymphocyte transformation may have been related to the factor which also inhibited red cell maturation.