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Coagulation in an Agarose Gel and its Application to the Detection and Measurement of Factor VIII Antibodies
Author(s) -
Bird Prudence
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb01827.x
Subject(s) - agarose , coagulation , fibrin , chemistry , antibody , thrombin , calcium , microbiology and biotechnology , chromatography , immunology , medicine , biology , platelet , organic chemistry
S ummary . Evidence has been presented that fibrin formation may be detected directly in agarose gels containing citrated plasma when they are treated with thrombin or calcium chloride. A new assay is described for haemophilic factor‐VIII antibody based on inhibition of fibrin formation within an agarose gel containing normal plasma.