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The Value of Age‐ and Sex‐Matched Controls for Coagulation Studies
Author(s) -
Dodds W. J.,
Moynihan A. C.,
Benson R. E.,
Hall C. A.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb01825.x
Subject(s) - venipuncture , coagulation , medicine , fibrinogen , factor vii , age groups , population , young adult , risk factor , biological age , physiology , endocrinology , demography , gerontology , surgery , environmental health , sociology
S ummary . Several coagulation parameters and plasminogen levels were studied in 80 normal people divided into eight paired and sex‐matched age groups: prepubertal children, postpuberal children, young adults, and adults over 50. The data indicate that factor‐VII and ‐IX activities increase with age, with a cluster of lower activity for children and higher activity for adults. Factor‐VIII levels appear to decrease with age, although this effect could be due to greater anxiety in the pre‐ and postpubertal children at the time of venipuncture. The adults showed no significant change in factor‐VIII activity with age, but partial data indicate that factor‐VIII levels are higher in adults with blood group A than those with blood group O. The age‐related changes in factor‐VII, ‐IX, and possibly ‐VIII activities did not vary between sexes. By contrast, plasminogen increased strikingly with age in males and decreased with age in females. With fibrinogen, a similar effect was found for adults, though not for the entire population. These findings indicate the importance of using appropriate age‐ and sex‐matched controls for coagulation and plasminogen assays, especially in patients with mild inherited or acquired coagulation disorders.