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Changes in Folate Metabolism in Baboons Papio cynocephalus Treated with 2‐Methyl‐2‐aminopropanol‐B 12
Author(s) -
Siddons R. C.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb01820.x
Subject(s) - metabolism , physiology , biology , medicine , endocrinology
S ummary . After the intramuscular administration of the vitamin B 12 analogue, 2‐methyl‐2‐aminopropanol‐B 12 , to vitamin B 12 ‐deplctcd baboons (Papio cynocephalus) the effects on vitamin B 12 and folate metabolism have been studied. The ‘apparent’ serum vitamin B 12 and the scrum folate concentrations increased, the liver folate concentrations decreased, and the liver vitamin B 12 concentrations were unchanged. The analogue caused a marked increase in the amount of formiminoglutamic acid excreted after a histidine load whereas the amount of methylmalonic acid excreted after a valine load decreased. The rate of red blood cell regeneration after venesection was normal in baboons treated with the analogue and there was no evidence of megaloblastic haemopoiesis. Two baboons given the analogue developed a partial loss of utilization and lack of co‐ordination in the hind limbs.