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Heterogeneity in Biological Activity of Human Factor VIII Antibodies
Author(s) -
Koutts J.,
Meyer D.,
Rickard K.,
Stott L.,
Firkin B. G.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb01803.x
Subject(s) - antibody , von willebrand factor , coagulation , antigen , immunology , intrinsic factor , chemistry , medicine , platelet , stomach
S ummary . Antibodies against factor VIII collected from six patients were studied for their effect on factor‐VIII coagulant activity, Willebrand factor activity (WF) and factor‐VIII‐related antigen. The results demonstrate differences between individual antibodies; some acting primarily as anti factor VIII, others inhibiting both factor VIII and WF. Differences in effect between plasma and serum indicate that the process of coagulation alters the interaction of these antibodies.