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The Relation between Morphology and Other Features of Acute Myeloid Leukaemia, and their Prognostic Significance: R eport of the M edical R esearch C ouncil 's W orking P arty on L eukaemia in A dults
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb00909.x
Subject(s) - bone marrow , myeloid leukaemia , myeloid , homogeneous , medicine , immunology , gastroenterology , combinatorics , mathematics
S ummary . 272 cases of acute myeloid leukaemia at all ages were allocated on the basis of May‐Grünwald‐Giemsa stained films of peripheral blood and bone marrow to seven morphological categories (M0‐M6), four of which were sub‐divided into poorly‐differentiated and well‐differentiated types. In all, 131 cases were considered to be poorly differentiated and 141 cases well differentiated. The 19 cases diagnosed as hypergranular promyelocytic leukaemia (M 3 ) formed a distinct and homogeneous group in respect of their low mean age, high incidence of haemorrhagic phenomena at presentation, low mean platelet count and neutrophil count, low remission rate and short survival. Aside from this group no significant relationships were apparent between the other morphological categories and the occurrence of remission and the duration of survival, although the duration of survival was slightly though not significantly shorter in the poorly‐differentiated group.