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Autoimmune Haemolytic Anaemia in New Zealand Black Mice
Author(s) -
East June,
Harvey Jennifer J.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb00897.x
Subject(s) - immunology , autoimmunity , autoimmune disease , virus , transplantation , biology , virology , malignancy , medicine , antibody , genetics
S ummary . Mice of the NZB strain spontaneously develop autoimmune haemolytic anaemia and reticulum cell neoplasms, and they harbour murine leukaemia virus. This triad of autoimmunity, malignancy, and virus infection is explored in experiments designed to show how the autoimmune haemolytic disease and/or the virus are transmitted to NZB hybrids derived naturally, by ovum transplantation, and from allophenic parents. Possible cellular mechanisms for the autoimmune process are reviewed, and evidence for a genetic, hormonal, or viral aetiology of autoimmune haemolytic anaemia is discussed.