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Chromosomal Abnormalities and Dyserythropoiesis in the Preleukaemic Phase of Multiple Myeloma
Author(s) -
Dahlke Miriam B.,
Nowell Peter C.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb00838.x
Subject(s) - multiple myeloma , bone marrow , preleukemia , medicine , melphalan , pathology , cancer research
S ummary . Two patients with multiple myeloma and one patient with a plasmacytoma are reported in whom acute leukaemia developed following long‐term treatment with melphalan. Each patient had a complete remission of the plasma cell disorder during which time the bone marrow was moderately to severely hypplastic. The end of the clinical remission was heralded by a dyserythropoietic anaemia which persisted several months before the emergence of the terminal acute leukaemia. Marked chromosomal abnormalities were observed in marrow cells during the dyserythropoietic phase.