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The Endotoxin‐induced Coagulant Activity of Human Monocytes
Author(s) -
Rivers R. P. A.,
Hathaway W. E.,
Weston W. L.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb00547.x
Subject(s) - monocyte , tissue factor , incubation , in vitro , lymphocyte , immunology , chemistry , cell , coagulation , microbiology and biotechnology , biology , medicine , biochemistry
S ummary . Leucocyte suspensions, exposed to endotoxin in vitro , develop coagulant activity which has been identified as tissue factor. Pure suspensions of polymorphonuclear (PMN) neutrophils, lymphocytes and monocytes were exposed to endotoxin and tested for tissue factor activity after 4 h incubation at 37°C. The results indicate that the monocyte is the cell primarily responsible for the endotoxininduced coagulant activity of mixed leucocyte suspensions, the small amount of activity demonstrated in PMN neutrophil and in lymphocyte suspensions at high cell concentrations being accounted for by monocyte contamination of less than 1%.