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The Effect of o‐Salicylate upon Pentose Phosphate Pathway Activity in Normal and G6PD‐Deficient Red Cells
Author(s) -
Worathumrong N.,
Grimes A. J.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb00536.x
Subject(s) - pentose phosphate pathway , salicylic acid , chemistry , aspirin , metabolite , biochemistry , pentose , enzyme , fermentation , glycolysis
S ummary . The effect of the major metabolite of aspirin, namely salicylic acid, upon the pentose phosphate pathway (PPP) of normal and G6PD‐deficient red cells has been studied. Salicylic acid was shown to inhibit this pathway in proportion to the amount present. At any concentration of this substance there was greater inhibition of the PPP in G6PD‐deficient than in normal red cells.