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Ultrastructure of Lymphocyte‐Mediated Cytotoxicity
Author(s) -
Tonietti G.,
Pecci G.,
Liberatore C.,
Salsano F.,
Fontana L.
Publication year - 1975
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1975.tb00519.x
Subject(s) - phytohaemagglutinin , ultrastructure , cytotoxicity , lymphocyte , pseudopodia , microbiology and biotechnology , biology , immunology , chemistry , cell , biochemistry , anatomy , in vitro
S ummary . The ultrastructural appearances of the interaction between normal phytohaemagglutinin (PHA)‐stimulated human lymphocytes and chicken red cells (ChRBC) were studied. Close contact between ChRBC and control non‐stimulated lymphocytes was often observed indicating that this is a non‐specific phenomenon. In mixtures of PHA‐stimulated lymphocytes and ChRBC, time‐dependent development of interdigitating pseudopods between the two cell types was observed which was not seen in controls. Their development followed the same time‐course as release of 51 Cr when the ChRBC were pre‐labelled with this marker. The findings suggest a relationship between the morphological changes observed and the destruction of the target cells (ChRBC).