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Chemical Heterogeneity of Foetal Haemoglobin in the Lepore Haemoglobinopathy
Author(s) -
Efremov G. D.,
Sadikario A.,
Stojmirovic E.,
Schroeder W. A.,
Roger Shelton J.,
Balog Shelton Joan,
Apell Gerald,
Wilson J. B.,
Brodie AnneR.,
Huisman T. H. J.
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb06799.x
Subject(s) - glycine , heterozygote advantage , genetics , alanine , chemistry , biology , amino acid , gene , genotype
S ummary . The glycine/alanine composition of the γCB‐3 peptide of haemoglobin F obtained from persons heterozygous and homozygous for haemoglobin Lepore has been determined. The mean glycine value for heterozygotes was 0.34 ± 0.1 residues which is similar to that observed in the haemoglobin F of normal adults. A higher glycine value was found in a homozygous individual. These findings are discussed with regard to the light which they shed on the molecular basis for the haemoglobin‐Lepore disorders and related types of δβ and β thalassaemia.