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Characteristics of a Novel Serum Vitamin‐B 12 ‐Binding Protein Associated with Hepatocellular Carcinoma
Author(s) -
Waxman Samuel,
Gilbert Harriet S.
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb06789.x
Subject(s) - vitamin b , hepatocellular carcinoma , vitamin b12 , antibody , vitamin , chemistry , microbiology and biotechnology , biology , biochemistry , immunology , cancer research
S ummary . A novel protein designated as hepatoma B 12 binder (HBB), the predominant vitamin‐B12‐binding protein in the serum of two adolescents with hepatocellular carcinoma, has been characterized. HBB is more acidic and has different electrophoretic mobility and elution behaviour on gel filtration than normal or chronic myeloid leukaemia transcobalamin I. HBB is a member of the family of‘R’type vitamin‐B12‐binding proteins since it immunologically cross reacts with anti‐R antibody and does not deliver vitamin B 12 to the cell. HBB is unique in that it is tumour‐related, elaborated in enormous quantity and possesses physical characteristics best explained by a different carbohydrate composition from that of transcobalamin I.