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The Effect of Some Liver Enzyme Inhibitors on the Hepatic Inactivation of Erythropoietin in Mice
Author(s) -
Loeber J. G.,
Bosch E.,
Goudsmit R.,
KolkVegter Annette J.
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb06783.x
Subject(s) - erythropoietin , disulfiram , endogeny , enzyme , pharmacology , chemistry , medicine , endocrinology , biochemistry
S ummary . In a series of experiments with polycythaemic mice the influence of liver enzyme inhibitors on erythropoietin activity was studied. SKF 525‐A was found to increase the half disappearance time of the activity of administered sheep erythropoietin. Both the administration of SKF‐525‐A and Disulfiram were found to increase the half disappearance time of endogenous erythropoietin activity. It is concluded that these compounds block the inactivation of erythropoietin in the liver. A model in which the action of such inhibitors on the disappearance of endogenous erythropoietin activity can be tested, is proposed.