Premium
Willebrand Factor and Ristocetin II. RELATIONSHIP BETWEEN WILLEBRAND FACTOR, WILLEBRAND ANTIGEN AND FACTOR‐VIII ACTIVITY
Author(s) -
Meyer D.,
Jenkins C. S. P.,
Dreyflis M. D.,
Fressinaud E.,
Lariueu M.J.
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb06676.x
Subject(s) - von willebrand factor , von willebrand disease , ristocetin , antigen , immunology , chemistry , medicine , platelet
S ummary . Two methods of assay of Willebrand factor activity have been used in the study of 20 patients with congenital and acquired von Willebrand's disease. The relationship between the three entities of factor‐VIII complex, Willebrand factor activity, Willebrand antigen and factor‐VIII activity is discussed. Data from thermo‐stability and dissociation studies favour the hypothesis that factor‐VIII complex consists of two closely related but separate proteins.