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Studies in Lipogeiiesis by Red Cells of Mice
Author(s) -
Pushpendran C. K.,
Eapen Jacob
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb06622.x
Subject(s) - cholesterol , chemistry , biochemistry , biology , endocrinology , medicine
S ummary . The incorporation of[1‐ 14 C]acetate,[U‐ 14 C]glucose and [1‐ 14 C]palmitate into lipids of red cells from 5‐, 30‐ and 180‐day‐old mice has been studied. The results show that the cells from 5‐ and 180‐day‐old mice have greater capacity for lipid synthesis than those from 30‐day‐old animals. Ghost preparations exhibit a similar pattern of incorporation but the levels of incorporation are higher than those of intact cells. There arc age‐dependent differences in the incorporation of the precursors into various types of lipids. The results show that there are changes in the levels of free fatty acids and triglycerides of red cells as a function of animal age. No quantitative changes were observed in phospholipids and cholesterol.