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A Study of Steroid‐Induced Granulocytosis in a Patient with Chronic Benign Neutropenia of Childhood
Author(s) -
Deinard Amos S.,
Page Arthur R.
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb00815.x
Subject(s) - granulocytosis , neutrophilia , neutropenia , medicine , absolute neutrophil count , immunology , endocrinology , granulocyte , chemotherapy
S ummary . An infant with chronic benign neutropenia of childhood was found to respond to a sudden, transient, stress‐induced rise in plasma corticoid level with a pronounced rise in peripheral neutrophil count. Neutrophil survival studies were performed following this stress‐induced neutrophilia and during and following hydrocortisone stimulation. Measurement of the decline in total neutrophil‐associated radioactivity showed that neurophils were removed from the circulation at a normal rate while measurement of neutrophil specific activity indicated that the observed steroid‐induced granulocytosis was a result of marrow released of neurtrophils.