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Vitamin E and Oxidative Damage by Tryptophan Metabolites in Experimental Enterogenous Cyanosis and Anaemia
Author(s) -
Westphal R. G.,
O'Meara T. M.
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb00498.x
Subject(s) - tryptophan , oxidative stress , vitamin c , vitamin e , oxidative phosphorylation , methemoglobin , glutathione , medicine , chemistry , endocrinology , oxidative damage , urine , antioxidant , biochemistry , biology , hemoglobin , amino acid , enzyme
S ummary . Experiments in rats with jejunal blind pouches and bacterial overgrowth demonstrate increased levels in red cells of reduced glutathione, suggesting oxidative stress on red cells, and decreased serum levels of vitamin E, a known anti‐oxidant. The urine of such animals contains increased amounts of tryptophan metabolites, some of which demonstrate strong oxidant activity as measured by methaemoglobin production in vitro. It is felt that enterogenous cyanosis, or intestinal autointoxication, does exist in this experimental model. Whether the oxidative damage previously described is due to the presence of the tryptophan metabolites, the low levels of vitamin E or both, cannot be unequivocally ascertained.