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Jaundice and Antibodies Directed against Factors VIII and IX in Patients Treated for Haemophilia or Christmas Disease in the United Kingdom
Author(s) -
Biggs Rosemary
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb00476.x
Subject(s) - jaundice , cryoprecipitate , medicine , haemophilia , incidence (geometry) , haemophilia a , antibody , disease , pediatrics , immunology , physics , optics , fibrinogen
S ummary . A study has been made of the incidence of jaundice and of antibodies directed against factors VIII and IX in patients treated for haemophilia and Christmas disease at 37 Haemophilia Centres in the United Kingdom during 1969–71. Records of 1837 patients were received and of these, 1625 (88.5%) had haemophilia and 212 (11.5%) had Christmas disease. The incidence of jaundice in all patients for the 3‐yr period was 3.48%. The average annual incidence of episodes of jaundice among patients treated in each year was 1.83%. The use of freeze dried concentrate (in comparison to cryoprecipitate) did not cause a dangerous increase in episodes of jaundice. The incidence of antibodies directed against factor VIII was 6–7%. The proportion did not increase over the 3‐yr period. There was no evidence of a familial tendency to develop antibodies directed against factor VIII.