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Serum Vitamin E Levels with Beta‐Thalassaemia Major: Preliminary Report
Author(s) -
ZannosMariolea L.,
Tzortzatou F.,
DendakiSvolaki K.,
Katerellos CH.,
Kavallari M.,
Matsaniotis N.
Publication year - 1974
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1974.tb00463.x
Subject(s) - vitamin e , medicine , vitamin , hydrogen peroxide , gastroenterology , chemistry , antioxidant , biochemistry
S ummary . Serum vitamin E levels were found to be below normal (<0.5 mg/100 ml) in 46% of 56 children with β‐thalassaemia major receiving inadequate treatment with blood transfusions. The difference between the mean vitamin E levels in the children with β‐thalassaemia as compared to that of normal children was highly significant ( P <0.001). The hydrogen peroxide lysis test was highly abnormal in all 21 children with β‐thalassaemia major in whom it was carried out; only 11 of them had vitamin E serum levels below normal (<0.5 mg/100 ml). Parenteral administration of 200 mg α‐tocopherol in six of the 21 children resulted in a normal hydrogen peroxide lysis test. It is noteworthy that two of the six children had normal vitamin E levels.