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Phenobarbitone Sensitivity of Jaundice in Haemolytic Patients
Author(s) -
Perona G.,
Corrocher R.,
Frezza M.,
Falezza G. C.,
Cellerino R.,
Tiribelli C.,
Fusaro A.,
Sandre G.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01785.x
Subject(s) - haemolysis , jaundice , bilirubin , medicine , gastroenterology , phenobarbital , immunology
S ummary . Eleven cases of chronic haemolytic jaundice treated with phenobarbitone are reported. In all patients, except one, the drug caused a significant reduction of hyperbilirubinaemia in spite of the persistence of an increased haemolysis. Radioactive bilirubin ( 3 H) kinetic studies demonstrated a bilirubin transfer defect from plasma to liver in seven patients which improved after phenobarbitone therapy along with the reduction of bilirubinaemia. It is concluded that a phenobarbitone‐sensitive hepatic mechanism frequently operates in producing jaundice in chronic haemolytic syndromes.