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Oxygen Transport in Anaemia
Author(s) -
Pollock A.,
Cotter K. P.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01776.x
Subject(s) - oxygen–haemoglobin dissociation curve , red cell , oxygen , iron deficiency , oxygen transport , chemistry , megaloblastic anaemia , medicine , anemia , folic acid , organic chemistry
S ummary . In three groups of anaemic patients, the haemoglobin‐oxygen (Hb‐O 2 ) dissociation curves were shifted to the right. The red cells of these patients contained increased amounts of 2,3‐diphosphoglycerate (2,3‐DPG). In iron‐deficiency anaemia and in megaloblastic anaemia there was a direct relationship between the degree of anaemia and the red cell 2,3‐DPG concentration, but this did not hold for the miscellaneous group, and no direct relationship could be demonstrated between the degree of change in the Hb‐O 2 dissociation curves and the degree of anaemia in any of the groups. The greatest increase in the red cell 2,3‐DPG concentration occurred in iron deficiency.